Wednesday, October 26, 2016

Water Quality and Food Safety – II

Waterborne Diseases 
Waterborne diseases are major causes of morbidity and mortality worldwide, because a person’s health may be affected by ingestion of contaminated water directly or through food. Nonetheless, person’s health may also be affected by the use of contaminated water for the purposes of personal hygiene and recreation. Thus problem is especially acute where general hygiene and environmental sanitation are poor and where there is inadequate supply of safe water, whereas developing countries carry a heavy burden of the water borne disease, the heaviest being the diarrheal diseases. Thus waterborne diseases are caused by pathogenic microorganisms that most commonly are transmitted in contaminated fresh water, whether in bathing, washing, drinking, or in the preparation of food, where various forms of diarrheal disease probably are the most common episodes occur in all countries, but they are 5 to 6 times more common in developing countries. According to the World Health Organization, it accounts for an estimated 4.1% of the total daily global burden of disease, causing about 1.8 million human deaths annually. The World Health Organization estimates that 88% of that burden is attributable to unsafe water supply, sanitation and hygiene, and is mainly affects children in developing countries.

Microorganisms causing characteristically waterborne diseases include protozoa and bacteria, many of which are intestinal parasites, or invade the tissues or circulatory system through walls of the digestive tract. Various other waterborne diseases are caused by viruses; as a matter of convenience in this connection they might well be regarded as microorganisms. Yet other important classes of water-borne diseases are caused by metazoan parasites. Typical examples include certain Nematoda, that is to say "roundworms", and also certain members of the Schistosomatidae, a family of blood flukes. The latter usually infect victims that make skin contact with the water.

The blood flukes are the pathogens causing Schistosomiasis of various forms, more or less seriously affecting hundreds of millions of people world-wide. As for Nematode infections, one important water-borne nematodal disease is Dracunculiasis. It is acquired by swallowing water in which copepoda occur, that happen to be infected with Nematode larvae in the genus Dracunculus. The larvae cause guinea worm disease.

Even before the establishment of the germ theory of disease, or any advanced understanding of the nature of water as a vehicle for transmitting disease, traditional beliefs cautioned against the consumption of water, rather favouring processed beverages such as beer, wine and tea. In the camel caravans that crossed Central Asia along the Silk Road, the explorer Owen Lattimore noted, "The reason we drank so much tea was because of the bad water. Water alone, unboiled, is never drunk. There is a superstition that it causes blisters on the feet."

The following tables give you some idea about various possible water borne diseases which happening across the globe. But when it comes to food safety, some of these diseases are having a minimal effect while some of them are having the critical effects. Thus we are going to discuss most of the food related water borne diseases and their prevention strategies as well as treatment methods in the later part of this series. 
   
Waterborne diseases are caused by pathogenic microorganisms, where they can be divided into several groups based on size and the types. 

PROTOZOAL INFECTIONS

Although all protozoal infectious agents in humans are parasites, by convention, parasitic diseases are defined as those caused by protozoa or helminthes. The old classification, in which a single phylum of protozoa encompassed all unicellular eukaryotic microorganisms, is no longer valid because of new ultra-structural and molecular taxonomic information. But here we consider the organisms classified under Amoebozoa, Excavata and Chromalveoata all together other than helminthes to simplify the classification since we are only considering the food safety aspects.

Disease and Transmission
Microbial Agent
Sources of Agent in Water Supply
General Symptoms
Amoebiasis (hand-to-mouth)
Protozoan (Entamoeba histolytica) (Cyst-like appearance)
Sewage, non-treated drinking water, flies in water supply
Abdominal discomfort, fatigue, weight loss, diarrhea, bloating, fever
Cryptosporidiosis (oral)
Protozoan (Cryptosporidium parvum)
Collects on water filters and membranes that cannot be disinfected, animal manure, seasonal runoff of water.
Flu-like symptoms, watery diarrhea, loss of appetite, substantial loss of weight, bloating, increased gas, nausea
Cyclosporiasis
Protozoan parasite (Cyclospora cayetanensis)
Sewage, non-treated drinking water
cramps, nausea, vomiting, muscle aches, fever, and fatigue
Giardiasis (fecal-oral) (hand-to-mouth)
Protozoan (Giardia lamblia) Most common intestinal parasite
Untreated water, poor disinfection, pipe breaks, leaks, groundwater contamination, campgrounds where humans and wildlife use same source of water. Beavers and muskrats create ponds that act as reservoirs for Giardia.
Diarrhea, abdominal discomfort, bloating, and flatulence
Microsporidiosis
Protozoan phylum (Microsporidia), but closely related to fungi
The genera of Encephalitozoon intestinalis has been detected in groundwater, the origin of drinking water
Diarrhea and wasting in immune-compromised individuals.
PARASITIC INFECTIONS
A parasite is an organism that lives on or in a host and gets its food from or at the expense of its host. Parasites can cause disease in humans. Some parasitic diseases are easily treated and some are not. The burden of these diseases often rests on communities in the tropics and subtropics, but parasitic infections also affect people in developed countries. There are three major groups, but we already discussed the first type the Protozoa.

Thus Helminths are multi-celled organisms that can live in or outside of your body. They’re more commonly known as worms. They include flatworms, tapeworms, thorny-headed worms, and roundworms.

Ectoparasites are multi-celled organisms that live on or feed off your skin. They include some insects and arachnids, such as mosquitos, fleas, ticks, and mites.

However, we only consider the organisms which are distributed by water and its food safety concerns.

Disease and Transmission
Microbial Agent
Sources of Agent in Water Supply
General Symptoms
Schistosomiasis (immersion)
Members of the genusSchistosoma
Fresh water contaminated with certain types of snails that carry schistosomes
Rash or itchy skin. Fever, chills, cough and muscle aches
Dracunculiasis (Guinea Worm Disease)
Dracunculus medinensis
Stagnant water containing larvae, generally in parasitised Copepoda
Allergic reaction, urticaria rash, nausea, vomiting, diarrhea, asthmatic attack.
Taeniasis
Tapeworms of the genus Taenia
Drinking water contaminated with eggs
Intestinal disturbances, neurologic manifestations, loss of weight, cysticercosis
Fasciolopsiasis
Fasciolopsis buski
Drinking water contaminated with encysted metacercaria
GIT disturbance, diarrhea, liver enlargement, cholangitis, cholecystitis, obstructive jaundice.
Hymenolepiasis (Dwarf Tapeworm Infection)
Hymenolepis nana
Drinking water contaminated with eggs
Abdominal pain, severe weight loss, itching around the anus, nervous manifestation
Echinococcosis (Hydatid disease)
Echinococcus granulosus
Drinking water contaminated with feces (usually canid) containing eggs
Liver enlargement, hydatid cysts press on bile duct and blood vessels; if cysts rupture they can cause anaphylactic shock
coenurosis
multiceps multiceps
contaminated drinking water with eggs
increases intacranial tension
Ascariasis
Ascaris lumbricoides
Drinking water contaminated with feces (usually canid) containing eggs
Mostly, disease is asymptomatic or accompanied by inflammation, fever, and diarrhea. Severe cases involve Löffler's syndrome in lungs, nausea, vomiting, malnutrition, and underdevelopment.
Enterobiasis
Enterobius vermicularis
Drinking water contaminated with eggs
Peri-anal itch, nervous irritability, hyperactivity and insomnia

VIRAL INFECTIONS
A virus is a small infectious organism—much smaller than a fungus or bacterium—that must invade a living cell to reproduce (replicate). The virus attaches to a cell (called the host cell), enters it, and releases its DNA or RNA inside the cell. The virus’s DNA or RNA is the genetic material containing the information needed to make copies of (replicate) the virus. The virus’s genetic material takes control of the cell and forces it to replicate the virus. The infected cell usually dies because the virus keeps it from performing its normal functions. When it dies, the cell releases new viruses, which go on to infect other cells. Viruses are classified as DNA viruses or RNA viruses, depending on whether they use DNA or RNA to replicate. 

Viruses usually infect one particular type of cell. For example, common cold viruses infect only cells of the upper respiratory tract. Viruses are spread (transmitted) in various ways. Some are swallowed, some are inhaled, and some are spread by the bites of insects, such as mosquitoes, certain biting flies, or ticks. Some are spread sexually or during transfusion of contaminated blood.

When a cell is infected with a virus several effects may be seen. Many viruses cause no harm or disease whatsoever. However, some viruses may attack certain cells and multiply within them. Once mature the daughter viruses break the cell and spread elsewhere. This is called a lytic infection. Eventually, if host immunity operates effectively, the virus-infected cell may be killed by the host, leading to interruption of the virus cycle and cure of the infection. However, this is not true for all viral infections. The viruses may persist in the cell without damaging it and make the cell a carrier. The patient may appear to be cured but the infection persists and can spread to others. In addition, the infection may reappear later after this period of lull or latency.

Disease and Transmission
Microbial Agent
Sources of Agent in Water Supply
General Symptoms
Adenovirus infection
Adenovirus
Manifests itself in improperly treated water
Symptoms include common cold symptoms, pneumonia, croup, and bronchitis
Gastroenteritis
Astrovirus, Calicivirus, Enteric Adenovirus, and Parvovirus
Manifests itself in improperly treated water
Symptoms include diarrhea, nausea, vomiting, fever, malaise, and abdominal pain
SARS (Severe Acute Respiratory Syndrome)
Coronavirus
Manifests itself in improperly treated water
Symptoms include fever, myalgia, lethargy, gastrointestinal symptoms, cough, and sore throat
Hepatitis A
Hepatitis A virus (HAV)
Can manifest itself in water (and food)
Symptoms are only acute (no chronic stage to the virus) and include Fatigue, fever, abdominal pain, nausea, diarrhea, weight loss, itching, jaundice and depression.
Poliomyelitis (Polio)
Poliovirus
Enters water through the feces of infected individuals
90-95% of patients show no symptoms, 4-8% have minor symptoms (comparatively) with delirium, headache, fever, and occasional seizures, and spastic paralysis, 1% have symptoms of non-paralytic aseptic meningitis. The rest have serious symptoms resulting in paralysis or death
Polyomavirus infection
Two of Polyomavirus: JC virus and BK virus
Very widespread, can manifest itself in water, ~80% of the population has antibodies to Polyomavirus
BK virus produces a mild respiratory infection and can infect the kidneys of immunosuppressed transplant patients. JC virus infects the respiratory system, kidneys or can cause progressive multifocal leukoencephalopathy in the brain (which is fatal).

BACTERIAL INFECTIONS
Bacteria are living things that have only one cell. Under a microscope, they look like balls, rods, or spirals. They are so small that a line of 1,000 could fit across a pencil eraser. Most bacteria won't hurt you - less than 1 percent of the different types make people sick. Many are helpful. Some bacteria help to digest food, destroy disease-causing cells, and give the body needed vitamins. Bacteria are also used in processing various foods such as yogurt and cheese.  

Bacterial infections are illnesses that occur when harmful forms of bacteria multiply inside the body. Harmful bacteria that cause bacterial infections and disease are called pathogenic bacteria. Bacterial diseases occur when pathogenic bacteria get into the body and begin to reproduce and crowd out healthy bacteria, or to grow in tissues that are normally sterile. Harmful bacteria may also emit toxins that damage the body. They range from mild to severe; although they include such deadly diseases such as plague, tuberculosis, and cholera.  However, most of the bacterial infections can be prevented by good sanitation or cured by antibiotics.

Bacteria are everywhere: in soil, in water, in air, and in the bodies of every person and animal. These microorganisms are among the most numerous forms of life on Earth. Most bacteria are either harmless, or helpful, or even essential to life. Bacteria break down (decompose) dead plants and animals. This allows chemical elements like carbon to return to the earth to be used again. In addition, some bacteria help plants get nitrogen. Without them, plants could not grow. In the human body, bacteria help keep the digestive tract working properly.

Disease and Transmission
Microbial Agent
Source of Agent in Water Supply
General Symptoms
Botulism
Clostridium botulinum
Bacteria can enter an open wound from contaminated water sources. Can enter the gastrointestinal tract by consuming contaminated drinking water or (more commonly) food
Dry mouth, blurred and/or double vision, difficulty swallowing, muscle weakness, difficulty breathing, slurred speech, vomiting and sometimes diarrhea. Death is usually caused by respiratory failure.
Campylobacteriosis
Most commonly caused by Campylobacter jejuni
Drinking water contaminated with feces
Produces dysentery like symptoms along with a high fever. Usually lasts 2–10 days.
Cholera
Spread by the bacterium Vibrio cholerae
Drinking water contaminated with the bacterium
In severe forms it is known to be one of the most rapidly fatal illnesses known. Symptoms include very watery diarrhea, nausea, cramps, nosebleed, rapid pulse, vomiting, and hypovolemic shock (in severe cases), at which point death can occur in 12–18 hours.
E. coli 
Certain strains of Escherichia coli (commonly E. coli)
Water contaminated with the bacteria
Mostly diarrhea. Can cause death in immunocompromised individuals, the very young, and the elderly due to dehydration from prolonged illness.
M. marinum
Mycobacterium marinum
Naturally occurs in water, most cases from exposure in swimming pools or more frequently aquariums; rare infection since it mostly infects immunocompromised individuals
Symptoms include lesions typically located on the elbows, knees, and feet (from swimming pools) or lesions on the hands (aquariums). Lesions may be painless or painful.
Dysentery
Caused by a number of species in the genera Shigella and Sallmonella with the most common being Shigella dysenteriae
Water contaminated with the bacterium
Frequent passage of feces with blood and/or mucus and in some cases vomiting of blood.
Legionellosis (two distinct forms: Legionnaires’ disease and Pontiac fever)
Caused by bacteria belonging to genus Legionella (90% of cases caused by Legionella pneumophila)
Contaminated water: the organism thrives in warm aquatic environments.
Pontiac fever produces milder symptoms resembling acute influenza without pneumonia. Legionnaires’ disease has severe symptoms such as fever, chills, pneumonia (with cough that sometimes produces sputum), ataxia, anorexia, muscle aches, malaise and occasionally diarrhea and vomiting
Leptospirosis
Caused by bacterium of genus Leptospira
Water contaminated by the animal urine carrying the bacteria
Begins with flu-like symptoms then resolves. The second phase then occurs involving meningitis, liver damage (causes jaundice), and renal failure
Otitis Externa (swimmer’s ear)
Caused by a number of bacterial and fungal species.
Swimming in water contaminated by the responsible pathogens
Ear canal swells causing pain and tenderness to the touch
Salmonellosis
Caused by many bacteria of genus Salmonella
Drinking water contaminated with the bacteria. More common as a food borne illness.
Symptoms include diarrhea, fever, vomiting, and abdominal cramps
Typhoid fever
Salmonella typhi
Ingestion of water contaminated with feces of an infected person
Characterized by sustained fever up to 40°C (104°F), profuse sweating, diarrhea, less commonly a rash may occur. Symptoms progress to delirium and the spleen and liver enlarge if untreated. In this case it can last up to four weeks and cause death.
Vibrio Illness
Vibrio vulnificus, Vibrio alginolyticus, and Vibrio parahaemolyticus
Can enter wounds from contaminated water. Also got by drinking contaminated water or eating undercooked oysters.
Symptoms include explosive, watery diarrhea, nausea, vomiting, abdominal cramps, and occasionally fever.

Sunday, October 23, 2016

Water Quality and Food Safety – I

Importance of Water
Water is the source essential to sustain the life on earth, since it is not only required for biological processes, where it’s abundant presence with typical physical and chemical characteristics are very important because water has a very stabilizing effect on interplanetary (sunlight, cosmic radiation and earthly (climate) processes. Nonetheless, water is the most important source of transportation on earth whereas cargos/goods that are transported through ships as primary transport source, while dissolved and suspended compounds are also transported where type and concentration of these compounds determine the water quality. Considering the total earth surface of 510 million sq.km, 73% of earth surface covers by it amounting to 1,600 million cubic kilometers. 

Thus satisfactory (adequate, safe and accessible) supply must be available to all as to the world health organization (WHO) because improving access to safe drinking-water can result in tangible benefits to health, where every effort should be made to achieve a drinking-water quality as safe as practicable. Safe drinking-water, as defined by the WHO guidelines, does not represent any significant risk to health over a lifetime of consumption, including different sensitivities that may occur between life stages. Those at greatest risk of waterborne disease are infants and young children, people who are debilitated or living under unsanitary conditions and the elderly. Safe drinking-water is suitable for all usual domestic purposes, including personal hygiene. Nonetheless, WHO guidelines are applicable to packaged water and ice intended for human consumption. However, water of higher quality may be required for some special purposes, such as renal dialysis and cleaning of contact lenses, or for certain purposes in food production and pharmaceutical use. Those who are severely immuno-compromised may need to take additional steps, such as boiling drinking water, due to their susceptibility to organisms that would not normally be of concern through drinking-water. However, WHO guidelines may not be suitable for the protection of aquatic life or for some industries.

Water Chemistry
Water is by far the most common liquid on the Earth’s surface, and its unique properties enable life to exist where water is usually regarded as a public resource or a common good, because it is essential for human life and society. However, water also is an economic resource which is sold as a commodity, and water rights in are one of the major reasons for continuous source of conflict in many civilizations. Beyond these perspectives, water holds a special place in human society.

As a recognized field of inquiry, water chemistry developed in the mid-twentieth century (late 1950s and early 1960s) at the dawn of the “environmental era”, whereas its origins as subareas of specialization in many other disciplines date back to the early twentieth century and even before. For example, the chemical composition of lakes and the oceans has been of interest to limnologists and oceanographers since the early development of those sciences in the late nineteenth century. Similarly, geochemists long have been interested in the composition of natural waters, in addition to longstanding interests in the composition of geo-solids. Water chemistry also was a significant component of the field of environmental engineering (or sanitary engineering, as it was known prior to about 1960), in part because of the important role of chemical processes in drinking water treatment. Werner Stumm (1924–1999) is widely considered to be the founding father of water chemistry. His contributions to the development of the field are both broad and deep, not only in terms of the span of his research contributions, but equally important as the mentor of many students who became leaders in the field and his authorship (with James Morgan, his first Ph.D. student) of the important textbook Aquatic Chemistry (1970).

For chemists, water is a small, simple-looking, and common molecule, H2O, but they also know it has many unusual and even unique properties, as discussed below. For civil engineers, water is a fluid to be transported via pipes and channels, and when it occurs in rivers and streams, it is viewed partly as an obstacle to transportation, for which bridges need to be designed and constructed, and partly as an energy-efficient means of transportation and shipping. Scientists in many other disciplines have their own viewpoints about water that reflect how it interacts with their science.

Water (H2O) in its purest form at room temperature is odorless, nearly colorless with a hint of blue and tasteless, which exist in nature as a polar inorganic compound. Due to its major property of being a universal solvent, it is in your body, the food you eat and the beverages you drink, which further help to clean yourself, clothes, dishes, car and everything else around you as well as you can travel on it or jump in it to cool off on hot summer days. Many of the products that you use every day contain water or were manufactured using it. At its most basic, water is a molecule with one oxygen atom and two hydrogen atoms, bonded together by shared electrons, which is a V-shaped polar molecule, and it is charged positively near the hydrogen atoms and negatively near the oxygen atom. Water molecules are naturally attracted and stick to each other because of this polarity, forming a hydrogen bond. This hydrogen bond is the reason behind many of water's special properties, such as the fact that it's denser in its liquid state than in its solid state (ice floats on water).

History of Water Treatments
The controlled use of water dates back to at least 8,000 B.C. when farmers in Egypt and parts of Asia trapped floodwaters for crop irrigation. Thus concept of using irrigation canals to bring water to crops, rather than waiting for a flood, was first developed about 2,000 B.C. in Egypt and Peru. The city of Karcho, what is now call Jordan, built two aqueducts to bring an adequate supply of water for the city's population by about 1,000 B.C. This is the first recorded instance of a planned municipal water supply.

Early water treatment was surprisingly advanced, although rarely practiced. An ancient Sanskrit manuscript, from what is now India, advises that drinking water should be kept in copper vessels, exposed to sunlight, and filtered through charcoal where ancient Egyptian inscriptions give similar advice. Many of these methods are still used today. The Greek medical practitioner Hippocrates suggested that water should be boiled and strained through a piece of cloth about 400 B.C. Despite these early references, most people drank untreated water from flowing streams or subterranean wells. As long as there were no sources of contamination nearby, this was a satisfactory solution.

As the population of Europe and other parts of the civilized world grew parallel to the industrial revolution, their sources of water became increasingly contaminated. Thus in many cities, in Europe and other parts, where  rivers that served as the primary sources of drinking water were so badly contaminated with sewage that they resembled open cesspools which act as host for Cholera, typhoid, and many other water-borne diseases. In 1800, William Cruikshank of England demonstrated that small doses of chlorine would kill germs in water and by the 1890s, several municipalities found that slowly filtering water through beds of sand could also significantly reduce the incidence of disease. The public outcry for safe drinking water reached such a crescendo that by the early 1900s where most major cities in the United States had installed some sort of water treatment system by that time.

Even through water treatment is established, water contamination remained a serious concern as an increasing amount of industrial wastes poured into the rivers and lakes. As the adverse health effects of lead, arsenic, pesticides, and other chemicals became known, the United States federal government was obliged to pass the Water Pollution Control Act of 1948. This was the first comprehensive legislation to define and regulate water quality, which was later followed by a series of increasingly tougher requirements, culminating in the current Environmental Protection Agency (EPA) water quality standards.

The Water Quality Parameters
Over the years water quality and attitudes towards it have changed greatly particularly in the food and beverage industries. The most significant criteria have been the appearance, especially in the beverage industry. However, factors such as taste have gained great importance over the years. However, probably the most important factor to arise in terms of quality due to water pollution is the quantity of coliform bacteria that is present in the water supply.

The appearance or turbidity is a measure of cloudiness and color, where accepted turbidity in most food and beverage production is 10 units. But ice has the exception with a turbidity factor of 5 units and most carbonated beverages with a turbidity factor of 2 units and water used in distilled spirits can have a turbidity factor as high as 10 units. Color is only specified for baked good at 10 units and carbonated beverages at 10 units and ice with 5 units.

Taste and odor of water is another important factor in food processing and the cleaning of the food processing machines/equipment. However there has yet to an absolute standard established for taste and odor for water in these applications. Since water is odorless, any water with a perceived odor could be considered unacceptable which is also true for taste even though water can often be described as tasting good or tasting bad. Water that tastes bad may contain dissolved mineral salts such as oxides from iron and/or organic matter such as dried leaves bacteria and algae.